AberrantKi-67expression through 3′UTR alternative polyadenylation in breast cancers
نویسندگان
چکیده
منابع مشابه
Aberrant Ki‐67 expression through 3′UTR alternative polyadenylation in breast cancers
Ki-67 (MKI67) is a marker of cellular proliferation of cancer. Here, we show that Ki-67 is post-transcriptionally regulated through alternative polyadenylation (APA) and microRNAs in breast cancer. We show that shortening of the Ki-67 3'UTR results in the loss of the binding sites for the suppressive miRNAs and thus renders the transcript with a shortened 3'UTR insusceptible to miRNA-mediated s...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2018
ISSN: 2211-5463
DOI: 10.1002/2211-5463.12364